An RNA-binding protein Blanks plays important roles in defining small RNA and mRNA profiles in Drosophila testes.
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ABSTRACT:
SUBMITTER: Liao SE
PROVIDER: S-EPMC6074722 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
An RNA-binding protein Blanks plays important roles in defining small RNA and mRNA profiles in <i>Drosophila</i> testes.
Liao Susan E SE Ai Yiwei Y Fukunaga Ryuya R
Heliyon 20180725 7
<i>Drosophila</i> Blanks is a testes-specific RNA-binding protein required for post-meiotic spermiogenesis. However, Blanks's role in regulating RNA populations in the testes remains unknown. We performed small RNA and mRNA high-throughput sequencing in <i>blanks</i> mutant testes and controls. We identified two miRNAs, one siRNA, and hundreds of mRNAs that are significantly upregulated or downregulated in <i>blanks</i> mutant testes. Pathway analysis revealed that differentially expressed mRNAs ...[more]
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