Ontology highlight
ABSTRACT:
SUBMITTER: Chen KS
PROVIDER: S-EPMC6075147 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Chen Kenneth S KS Stroup Emily K EK Budhipramono Albert A Rakheja Dinesh D Nichols-Vinueza Diana D Xu Lin L Stuart Sarai H SH Shukla Abhay A AA Fraire Claudette C Mendell Joshua T JT Amatruda James F JF
Genes & development 20180719 15-16
Many childhood Wilms tumors are driven by mutations in the microRNA biogenesis machinery, but the mechanism by which these mutations drive tumorigenesis is unknown. Here we show that the transcription factor <i>pleomorphic adenoma gene 1 (PLAG1</i>) is a microRNA target gene that is overexpressed in Wilms tumors with mutations in microRNA processing genes. Wilms tumors can also overexpress <i>PLAG1</i> through copy number alterations, and <i>PLAG1</i> expression correlates with prognosis in Wilm ...[more]