Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.
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ABSTRACT:
SUBMITTER: Spracklen CN
PROVIDER: S-EPMC6075203 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.
Spracklen Cassandra N CN Chen Peng P Kim Young Jin YJ Wang Xu X Cai Hui H Li Shengxu S Long Jirong J Wu Ying Y Wang Ya Xing YX Takeuchi Fumihiko F Wu Jer-Yuarn JY Jung Keum-Ji KJ Hu Cheng C Akiyama Koichi K Zhang Yonghong Y Moon Sanghoon S Johnson Todd A TA Li Huaixing H Dorajoo Rajkumar R He Meian M Cannon Maren E ME Roman Tamara S TS Salfati Elias E Lin Keng-Hung KH Guo Xiuqing X Sheu Wayne H H WHH Absher Devin D Adair Linda S LS Assimes Themistocles L TL Aung Tin T Cai Qiuyin Q Chang Li-Ching LC Chen Chien-Hsiun CH Chien Li-Hsin LH Chuang Lee-Ming LM Chuang Shu-Chun SC Du Shufa S Fan Qiao Q Fann Cathy S J CSJ Feranil Alan B AB Friedlander Yechiel Y Gordon-Larsen Penny P Gu Dongfeng D Gui Lixuan L Guo Zhirong Z Heng Chew-Kiat CK Hixson James J Hou Xuhong X Hsiung Chao Agnes CA Hu Yao Y Hwang Mi Yeong MY Hwu Chii-Min CM Isono Masato M Juang Jyh-Ming Jimmy JJ Khor Chiea-Chuen CC Kim Yun Kyoung YK Koh Woon-Puay WP Kubo Michiaki M Lee I-Te IT Lee Sun-Ju SJ Lee Wen-Jane WJ Liang Kae-Woei KW Lim Blanche B Lim Sing-Hui SH Liu Jianjun J Nabika Toru T Pan Wen-Harn WH Peng Hao H Quertermous Thomas T Sabanayagam Charumathi C Sandow Kevin K Shi Jinxiu J Sun Liang L Tan Pok Chien PC Tan Shu-Pei SP Taylor Kent D KD Teo Yik-Ying YY Toh Sue-Anne SA Tsunoda Tatsuhiko T van Dam Rob M RM Wang Aili A Wang Feijie F Wang Jie J Wei Wen Bin WB Xiang Yong-Bing YB Yao Jie J Yuan Jian-Min JM Zhang Rong R Zhao Wanting W Chen Yii-Der Ida YI Rich Stephen S SS Rotter Jerome I JI Wang Tzung-Dau TD Wu Tangchun T Lin Xu X Han Bok-Ghee BG Tanaka Toshihiro T Cho Yoon Shin YS Katsuya Tomohiro T Jia Weiping W Jee Sun-Ha SH Chen Yuan-Tsong YT Kato Norihiro N Jonas Jost B JB Cheng Ching-Yu CY Shu Xiao-Ou XO He Jiang J Zheng Wei W Wong Tien-Yin TY Huang Wei W Kim Bong-Jo BJ Tai E-Shyong ES Mohlke Karen L KL Sim Xueling X
Human molecular genetics 20170501 9
Large-scale meta-analyses of genome-wide association studies (GWAS) have identified >175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). With differences in linkage disequilibrium (LD) structure and allele frequencies between ancestry groups, studies in additional large samples may detect new associations. We conducted staged GWAS meta-analyses in ...[more]
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