Impacts of Recurrent Hitchhiking on Divergence and Demographic Inference in Drosophila.

ABSTRACT: In species with large population sizes such as Drosophila, natural selection may have substantial effects on genetic diversity and divergence. However, the implications of this widespread nonneutrality for standard population genetic assumptions and practices remain poorly resolved. Here, we assess the consequences of recurrent hitchhiking (RHH), in which selective sweeps occur at a given rate randomly across the genome. We use forward simulations to examine two published RHH models for D. melanogaster, reflecting relatively common/weak and rare/strong selection. We find that unlike the rare/strong RHH model, the common/weak model entails a slight degree of Hill-Robertson interference in high recombination regions. We also find that the common/weak RHH model is more consistent with our gen

SUBMITTER: Lange JD 

PROVIDER: S-EPMC6075209 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature