Ontology highlight
ABSTRACT:
SUBMITTER: Marcogliese PC
PROVIDER: S-EPMC6075539 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Marcogliese Paul C PC Abuaish Sameera S Kabbach Ghassan G Abdel-Messih Elizabeth E Seang Sarah S Li Gang G Slack Ruth S RS Haque M Emdadul ME Venderova Katerina K Park David S DS
Human molecular genetics 20170401 7
Progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta is the primary cause for motor symptoms observed in Parkinson's disease (PD). Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most commonly linked contributor to familial PD. LRRK2 is suggested to be involved in a wide variety of cellular processes, but deciphering its role in the pathogenesis of PD has been difficult. Modelling PD in rodents has been a persistent challenge for the field. However, th ...[more]