Integrated Molecular Characterization of Testicular Germ Cell Tumors.
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ABSTRACT:
SUBMITTER: Shen H
PROVIDER: S-EPMC6075738 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Integrated Molecular Characterization of Testicular Germ Cell Tumors.
Shen Hui H Shih Juliann J Hollern Daniel P DP Wang Linghua L Bowlby Reanne R Tickoo Satish K SK Thorsson Vésteinn V Mungall Andrew J AJ Newton Yulia Y Hegde Apurva M AM Armenia Joshua J Sánchez-Vega Francisco F Pluta John J Pyle Louise C LC Mehra Rohit R Reuter Victor E VE Godoy Guilherme G Jones Jeffrey J Shelley Carl S CS Feldman Darren R DR Vidal Daniel O DO Lessel Davor D Kulis Tomislav T Cárcano Flavio M FM Leraas Kristen M KM Lichtenberg Tara M TM Brooks Denise D Cherniack Andrew D AD Cho Juok J Heiman David I DI Kasaian Katayoon K Liu Minwei M Noble Michael S MS Xi Liu L Zhang Hailei H Zhou Wanding W ZenKlusen Jean C JC Hutter Carolyn M CM Felau Ina I Zhang Jiashan J Schultz Nikolaus N Getz Gad G Meyerson Matthew M Stuart Joshua M JM Akbani Rehan R Wheeler David A DA Laird Peter W PW Nathanson Katherine L KL Cortessis Victoria K VK Hoadley Katherine A KA
Cell reports 20180601 11
We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited high aneuploidy and a paucity of somatic mutations. Somatic mutation of only three genes achieved significance-KIT, KRAS, and NRAS-exclusively in samples with seminoma components. Integrated analyses identified distinct molecular patterns that characterized the major recognized histologic subtypes of TGCT: seminoma, embryo ...[more]
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