Ontology highlight
ABSTRACT:
SUBMITTER: Palmai Z
PROVIDER: S-EPMC6075769 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
PloS one 20180803 8
NMDA-type glutamate receptors (NMDAR) are ligand-gated ion channels that contribute to excitatory neurotransmission in the central nervous system. NMDAR dysfunction has been found to be involved in various neurological disorders. Recent crystallographic and EM studies have shown the static structure of different states of the non-human NMDARs. Here we describe a model of a human NMDA receptor (hNMDAR) and its molecular dynamics (MD) before and after the binding of agonist ligands, glutamate and ...[more]