Radical change of apoptotic strategy following irradiation during later period of embryogenesis in medaka (Oryzias latipes).

ABSTRACT: Induction of apoptosis in response to various genotoxic stresses could block transmission of teratogenic mutations to progeny cells. The severity of biological effects following irradiation depends on the stage at which embryos are irradiated during embryogenesis. We reported previously that irradiation of medaka embryos 3 days post fertilization (dpf) with 10 Gy of gamma rays induced high incidence of apoptotic cells in the mid-brain, however, the embryos hatched normally and developed without apparent malformations. To determine the severity of biological effects following irradiation during a later period of embryogenesis, embryos of various developmental stages were irradiated with 15 Gy of gamma rays and examined for apoptotic induction at 24 h after irradiation in the brain, eyes and

SUBMITTER: Yasuda T 

PROVIDER: S-EPMC6075778 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature