Expression and localization of the polarity protein CRB2 in adult mouse brain: a comparison with the CRB1^rd8 mutant mouse model.

ABSTRACT: Acquisition of cell polarization is essential for the performance of crucial functions, like a successful secretion and appropriate cell signaling in many tissues, and it depends on the correct functioning of polarity proteins, including the Crumbs complex. The CRB proteins, CRB1, CRB2 and CRB3, identified in mammals, are expressed in epithelial-derived tissues like brain, kidney and retina. CRB2 has a ubiquitous expression and has been detected in embryonic brain tissue; but currently there is no data regarding its localization in the adult brain. In our study, we characterized the presence of CRB2 in adult mice brain, where it is particularly enriched in cortex, hippocampus, hypothalamus and cerebellum. Double immunofluorescence analysis confirmed that CRB2 is a neuron-specific protein,

SUBMITTER: Dolon JF 

PROVIDER: S-EPMC6076319 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature