Ontology highlight
ABSTRACT:
SUBMITTER: Bushart DD
PROVIDER: S-EPMC6077100 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Bushart David D DD Shakkottai Vikram G VG
Neuroscience letters 20180205
Cerebellar ataxias constitute a heterogeneous group of disorders that result in impaired speech, uncoordinated limb movements, and impaired balance, often ultimately resulting in wheelchair confinement. Motor dysfunction in ataxia can be attributed to dysfunction and degeneration of neurons in the cerebellum and its associated pathways. Recent work has suggested the importance of cerebellar neuronal dysfunction resulting from mutations in specific ion-channels that regulate membrane excitability ...[more]