An Evaluation of Neurotoxicity Following Fluoride Exposure from Gestational Through Adult Ages in Long-Evans Hooded Rats.

ABSTRACT: At elevated levels, fluoride (F^-) exposure has been associated with adverse human health effects. In rodents, F^- exposure has been reported to induce deficits in motor performance and learning and memory. In this study, we examined Long-Evans hooded male rats maintained on a standard diet (20.5 ppm F^-) or a low F^- diet (3.24 ppm F^-) with drinking water exposure to 0, 10, or 20 ppm F^- from gestational day 6 through adulthood. At postnatal day 25, brain F^- levels were 0.048 or 0.081 μg/g and femur 235 or 379.8 μg/g for 10 and 20 ppm F^-, respectively. Levels increase with age and in adults, levels for plasma were 0.036 or 0.025 μg/ml; for the brain 0.266 or 0.850 μg/g; and for the femur, 681.2 or 993.4 μg/

SUBMITTER: McPherson CA 

PROVIDER: S-EPMC6077107 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature