Ontology highlight
ABSTRACT:
SUBMITTER: Hoard TM
PROVIDER: S-EPMC6077130 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Hoard Tyler M TM Yang Xiao Ping XP Jetten Anton M AM ZeRuth Gary T GT
Heliyon 20180725 7
Gli-similar 3 (Glis3) is Krüppel-like transcription factor associated with the transcriptional regulation of insulin. Mutations within the Glis3 locus have been implicated in a number of pathologies including diabetes <i>mellitus</i> and hypothyroidism. Despite its clinical significance, little is known about the proteins and posttranslational modifications that regulate Glis3 transcriptional activity. In this report, we demonstrate that the SUMO-pathway associated proteins, PIASy and Ubc9 are c ...[more]