A Virally Encoded DeSUMOylase Activity Is Required for Cytomegalovirus Reactivation from Latency.
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ABSTRACT:
SUBMITTER: Poole EL
PROVIDER: S-EPMC6077246 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
A Virally Encoded DeSUMOylase Activity Is Required for Cytomegalovirus Reactivation from Latency.
Poole Emma L EL Kew Verity G VG Lau Jonathan C H JCH Murray Matthew J MJ Stamminger Thomas T Sinclair John H JH Reeves Matthew B MB
Cell reports 20180701 3
A subset of viral genes is required for the long-term latent infection of hematopoietic cells by human cytomegalovirus (HCMV). Here, we show that a latency-associated gene product (LUNA) promotes the disruption of cellular PML bodies during latency. Mutation and inhibitor studies reveal that LUNA encodes a deSUMOylase activity responsible for this disruption. Specifically, LUNA encodes a conserved Asp-Cys-Gly motif common to all deSUMOylases. Importantly, mutation of the putative catalytic cyste ...[more]
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