Ontology highlight
ABSTRACT:
SUBMITTER: Vazquez Rodriguez G
PROVIDER: S-EPMC6077262 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Vazquez Rodriguez Gabriela G Abrahamsson Annelie A Jensen Lasse Dahl Ejby LDE Dabrosin Charlotta C
Frontiers in immunology 20180730
Fat is a major tissue component in human breast cancer (BC). Whether breast adipocytes (BAd) affect early stages of BC metastasis is yet unknown. BC progression is dependent on angiogenesis and inflammation, and interleukin-8 (IL-8) and vascular endothelial growth factor (VEGF) are key regulators of these events. Here, we show that BAd increased the dissemination of estrogen receptor positive BC cells (BCC) <i>in vivo</i> in the zebrafish model of metastasis, while dissemination of the more aggr ...[more]