Ontology highlight
ABSTRACT:
SUBMITTER: Mangahas JL
PROVIDER: S-EPMC60777 | biostudies-literature | 2001 Dec
REPOSITORIES: biostudies-literature
Mangahas J L JL Alexander M K MK Sandell L L LL Zakian V A VA
Molecular biology of the cell 20011201 12
Removal of a telomere from yeast chromosome VII in a strain having two copies of this chromosome often results in its loss. Here we show that there are three pathways that can stabilize this broken chromosome: homologous recombination, nonhomologous end joining, and de novo telomere addition. Both in a wild-type and a recombination deficient rad52 strain, most stabilization events were due to homologous recombination, whereas nonhomologous end joining was exceptionally rare. De novo telomere add ...[more]