Ontology highlight
ABSTRACT:
SUBMITTER: Xiao T
PROVIDER: S-EPMC6077722 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20180709 31
Endocrine therapy resistance invariably develops in advanced estrogen receptor-positive (ER<sup>+</sup>) breast cancer, but the underlying mechanisms are largely unknown. We have identified C-terminal SRC kinase (CSK) as a critical node in a previously unappreciated negative feedback loop that limits the efficacy of current ER-targeted therapies. Estrogen directly drives CSK expression in ER<sup>+</sup> breast cancer. At low CSK levels, as is the case in patients with ER<sup>+</sup> breast cance ...[more]