Ontology highlight
ABSTRACT:
SUBMITTER: Triplett TA
PROVIDER: S-EPMC6078800 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Triplett Todd A TA Garrison Kendra C KC Marshall Nicholas N Donkor Moses M Blazeck John J Lamb Candice C Qerqez Ahlam A Dekker Joseph D JD Tanno Yuri Y Lu Wei-Cheng WC Karamitros Christos S CS Ford Kyle K Tan Bing B Zhang Xiaoyan M XM McGovern Karen K Coma Silvia S Kumada Yoichi Y Yamany Mena S MS Sentandreu Enrique E Fromm George G Tiziani Stefano S Schreiber Taylor H TH Manfredi Mark M Ehrlich Lauren I R LIR Stone Everett E Georgiou George G
Nature biotechnology 20180716 8
Increased tryptophan (Trp) catabolism in the tumor microenvironment (TME) can mediate immune suppression by upregulation of interferon (IFN)-γ-inducible indoleamine 2,3-dioxygenase (IDO1) and/or ectopic expression of the predominantly liver-restricted enzyme tryptophan 2,3-dioxygenase (TDO). Whether these effects are due to Trp depletion in the TME or mediated by the accumulation of the IDO1 and/or TDO (hereafter referred to as IDO1/TDO) product kynurenine (Kyn) remains controversial. Here we sh ...[more]