Main and interactive effects of physical activity, fitness and body mass in the prevention of cancer from the Copenhagen Male Study.

ABSTRACT: Little knowledge exists about the role of cardiorespiratory fitness (CRF) or its interaction with excess adiposity determined by body mass index (BMI) in cancer prevention. A total of 5,128 middle-aged men, without a history of cancer at baseline in 1970-71, were examined for subsequent incidence and mortality of several cancer types. Participants' data were linked with cancer registration and mortality data to March 2017. During 47 years of follow-up, a total of 1,920 incident cases and 1,638 cancer-related deaths were ascertained. BMI, particularly obesity, was associated with (i) incidence and (ii) mortality from respiratory/thoracic cancers; and (iii) all cancer-cause mortality. The respective adjusted hazard ratios (HRs) were: (i) 0.51 (95%CI:0.32-0.79), (ii) 0.48 (95%CI:0.30-0.75) an

SUBMITTER: Nunez C 

PROVIDER: S-EPMC6078972 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature