Ontology highlight
ABSTRACT:
SUBMITTER: Tian B
PROVIDER: S-EPMC6079005 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nature communications 20180806 1
Multiphoton imaging techniques that convert low-energy excitation to higher energy emission are widely used to improve signal over background, reduce scatter, and limit photodamage. Lanthanide-doped upconverting nanoparticles (UCNPs) are among the most efficient multiphoton probes, but even UCNPs with optimized lanthanide dopant levels require laser intensities that may be problematic. Here, we develop protein-sized, alloyed UCNPs (aUCNPs) that can be imaged individually at laser intensities >30 ...[more]