Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC6079242 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Chen Jintong J Zhao Yinghua Y Jiang Yuxue Y Gao Sujun S Wang Yiming Y Wang Dongjiao D Wang Alison A Yi Huanfa H Gu Rui R Yi Qing Q Wang Siqing S
Frontiers in immunology 20180731
We recently discovered that dectin-1-activated dendritic cells (DCs) drive potent T helper (Th) 9 cell responses and antitumor immunity. However, the underlying mechanisms need to be further defined. The cytokine microenvironment is critical for Th cell differentiation. Here, we show that dectin-1 activation enhances interleukin (IL)-33 expression in DCs. We found that blocking IL-33/ST2 inhibits dectin-1-activated DC-induced Th9 cell differentiation. More importantly, the addition of IL-33 furt ...[more]