Significance of Preoperative Systemic Immune Score for Stage I Gastric Cancer Patients.

ABSTRACT: Background:Determining preferences regarding the benefits of adjuvant chemotherapy (AC) for stage I GC is critical. Methods:We retrospectively reviewed 1069 patients with pathologically confirmed stage I GC who underwent R0 gastrectomy between 2006 and 2014. Univariate and multivariate survival analyses were conducted. Systemic inflammation factors were used to develop a scoring system for predicting AC benefits. Results:With a median follow-up of 47 months (range 3-113 months), the 5-year overall survival (OS) rate was 90.5%. The patient score was 1 for either a pretreatment hypoalbuminemia or elevated derived neutrophil-lymphocyte ratio (dNLR) and was 0 otherwise. The SIS served as an independent prognostic factor for reduced OS. AC was delivered to 13.5% (144/1069) of all patients. Compared to surgery alone, AC had no significant effect on survival in both the entire cohort and the IA/IB subgroup. However, in the high-risk group (SIS?=?2), patients with AC had a significantly better OS than those undergoing surgery alone. Conclusions:Patients with SIS?=?2 may benefit from AC and thus may be considered candidates for adjuvant treatment. However, to confirm our findings, future prospective studies are warranted.

SUBMITTER: Lu J 

PROVIDER: S-EPMC6079442 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature