Dataset Information
Significance of Preoperative Systemic Immune Score for Stage I Gastric Cancer Patients.
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ABSTRACT: Background
Determining preferences regarding the benefits of adjuvant chemotherapy (AC) for stage I GC is critical.Methods
We retrospectively reviewed 1069 patients with pathologically confirmed stage I GC who underwent R0 gastrectomy between 2006 and 2014. Univariate and multivariate survival analyses were conducted. Systemic inflammation factors were used to develop a scoring system for predicting AC benefits.Results
With a median follow-up of 47 months (range 3-113 months), the 5-year overall survival (OS) rate was 90.5%. The patient score was 1 for either a pretreatment hypoalbuminemia or elevated derived neutrophil-lymphocyte ratio (dNLR) and was 0 otherwise. The SIS served as an independent prognostic factor for reduced OS. AC was delivered to 13.5% (144/1069) of all patients. Compared to surgery alone, AC had no significant effect on survival in both the entire cohort and the IA/IB subgroup. However, in the high-risk group (SIS = 2), patients with AC had a significantly better OS than those undergoing surgery alone.Conclusions
Patients with SIS = 2 may benefit from AC and thus may be considered candidates for adjuvant treatment. However, to confirm our findings, future prospective studies are warranted.
SUBMITTER: Lu J
PROVIDER: S-EPMC6079442 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Significance of Preoperative Systemic Immune Score for Stage I Gastric Cancer Patients.
Gastroenterology research and practice 20180711
<h4>Background</h4>Determining preferences regarding the benefits of adjuvant chemotherapy (AC) for stage I GC is critical.<h4>Methods</h4>We retrospectively reviewed 1069 patients with pathologically confirmed stage I GC who underwent R0 gastrectomy between 2006 and 2014. Univariate and multivariate survival analyses were conducted. Systemic inflammation factors were used to develop a scoring system for predicting AC benefits.<h4>Results</h4>With a median follow-up of 47 months (range 3-113 mon ...[more]