Dataset Information

Brain tissue pulsatility is related to clinical features of Parkinson's disease.

ABSTRACT:

Introduction

This study investigated whether brain tissue pulsatility is associated with features of disease severity in Parkinson's disease (PD).

Methods

Data were extracted from the Parkinson's Progression Markers Initiative among 81 adults with PD (confirmed with DATSCAN™). Brain tissue pulsatility was computed using resting state blood oxygenation level dependent (BOLD) MRI in white matter (WM), referred to as BOLD_TP. Motor impairment was assessed using the Movement Disorders Society unified Parkinson's disease rating scale. Factor analysis generated composite scores for cognition and vascular risk burden. A linear regression model examined the association of BOLD_TP with age, sex, motor impairment, cognition, vascular risk burden and PD duration. In addition, we investigated whether BOLD_TP relates to WM hyperintensity (WMH) volume, WM fractional anisotropy (WM-FA) and striatal binding ratio (SBR) of dopamine transporter.

Results

Motor impairment (t?=?2.3, p?=?.02), vascular burden (t?=?2.4, p?=?.02) and male sex (t?=?3.0, p?=?.003) were independently associated with BOLD_TP (r²?=?0.40, p?TP was correlated with WMH volume (r?=?0.22, p?=?.05) but not WM-FA nor SBR (p?>?.1). In addition, BOLD_TP (t?=?2.76, p?=?.008) and SBR (t?=?-2.04, p?=?.04) were independently related to motor impairment (r²?=?0.18, p?=?.006).

Conclusion

Our findings show that brain tissue pulsatility from BOLD images in WM is related to neurological and vascular features in PD. BOLD_TP may be useful in PD to study small vessel alterations that appear distinct from WM structural changes.

SUBMITTER: Shirzadi Z

PROVIDER: S-EPMC6079564 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Brain tissue pulsatility is related to clinical features of Parkinson's disease.

Shirzadi Zahra Z Robertson Andrew D AD Metcalfe Arron W AW Duff-Canning Sarah S Marras Connie C Lang Anthony E AE Masellis Mario M MacIntosh Bradley J BJ

NeuroImage. Clinical 20180723

<h4>Introduction</h4>This study investigated whether brain tissue pulsatility is associated with features of disease severity in Parkinson's disease (PD).<h4>Methods</h4>Data were extracted from the Parkinson's Progression Markers Initiative among 81 adults with PD (confirmed with DATSCAN™). Brain tissue pulsatility was computed using resting state blood oxygenation level dependent (BOLD) MRI in white matter (WM), referred to as BOLD<sub>TP</sub>. Motor impairment was assessed using the Movement ...[more]

PMID: 30090696

Similar Datasets

Project description:Parkinson’s disease is second most prevalent neurodegenerative disorder. Parkinson’s disease is hypothesized to be caused by a multifaceted interplay between genetic and environmental factors. We profiled the DNA methylation using the frontal lobe from people who died from Parkinson’s disease and compared them with age-, and sex-matched controls. We hypothesized that the complex regulation of DNA methylation and metabolome leads to deficits that cause irregular motor function among Parkinson’s disease subjects and the metabolomic disparities may reflect the effect of these complex interactions. Herein, we aim to integrate quantitative metabolomics and DNA methylation of brain tissue from primary motor cortex (Brodmann area 4) from Parkinson’s disease sufferers to better understand the biochemistry associated with the onset of the disease. Parkinson’s disease (PD) is second most prevalent neurodegenerative disorder following Alzheimer’s disease. Parkinson’s disease is hypothesized to be caused by a multifaceted interplay between genetic and environmental factors. Herein, and for the first time, we describe the integration of metabolomics and epigenetics (genome-wide DNA methylation; epimetabolomics) to profile the frontal lobe from people who died from PD and compared them with age-, and sex-matched controls. We identified 48 metabolites to be at significantly different concentrations (FDR q<0.05), 4,313 differentially methylated sites [5'-C-phosphate-G-3' (CpGs)] (FDR q<0.05) and increased DNA methylation age in the primary motor cortex of people who died from PD. We identified Primary bile acid biosynthesis as the major biochemical pathway to be perturbed in the frontal lobe of PD sufferers, and the metabolite taurine (p-value = 5.91E-06) as being positively correlated with CpG cg14286187 (SLC25A27; CYP39A1) (FDR q = 0.002), highlighting previously unreported biochemical changes associated with PD pathogenesis. In this novel multi-omics study, we identify regulatory mechanisms which we believe warrant future translational investigation and central biomarkers of PD which require further validation in more accessible biomatrices.

Dataset Information

Brain tissue pulsatility is related to clinical features of Parkinson's disease.

Introduction

Methods

Results

Conclusion

Publications

Brain tissue pulsatility is related to clinical features of Parkinson's disease.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure