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All-trans-retinoic-acid and arsenic trioxide induced remission in promyelocytic blast crisis.


ABSTRACT: A 78-year-old-male with chronic myeloid leukemia (CML) treated for seven years with dasatinib developed an acute promyelocytic leukemia complicated by disseminated intravascular coagulopathy. A promyelocytic blast crisis was diagnosed by demonstrating co-expression of chimeric BCL/ABL and PML/RAR? translocations by karyotyping, fluorescence in situ hybridization, and quantitative real-time polymerase chain reaction. Promyelocytic blast crisis of CML is a rare event with historically poor outcomes. Treatment of our patient with all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) resulted in complete morphologic remission. We review here the relevant literature of promyelocytic blast crisis and highlight the potential of ATRA/ATO as first line management.

SUBMITTER: Colvin TA 

PROVIDER: S-EPMC6079565 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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All-<i>trans</i>-retinoic-acid and arsenic trioxide induced remission in promyelocytic blast crisis.

Colvin Teresa A TA   Vachhani Pankit P   Sait Sheila S   Neppalli Vishala V   Wang Eunice S ES  

Leukemia research reports 20180725


A 78-year-old-male with chronic myeloid leukemia (CML) treated for seven years with dasatinib developed an acute promyelocytic leukemia complicated by disseminated intravascular coagulopathy. A promyelocytic blast crisis was diagnosed by demonstrating co-expression of chimeric <i>BCL/ABL</i> and <i>PML/RARα</i> translocations by karyotyping, fluorescence in situ hybridization, and quantitative real-time polymerase chain reaction. Promyelocytic blast crisis of CML is a rare event with historicall  ...[more]

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