Ontology highlight
ABSTRACT:
SUBMITTER: Bonanno JB
PROVIDER: S-EPMC60796 | biostudies-literature | 2001 Nov
REPOSITORIES: biostudies-literature
Bonanno J B JB Edo C C Eswar N N Pieper U U Romanowski M J MJ Ilyin V V Gerchman S E SE Kycia H H Studier F W FW Sali A A Burley S K SK
Proceedings of the National Academy of Sciences of the United States of America 20011101 23
X-ray structures of two enzymes in the sterol/isoprenoid biosynthesis pathway have been determined in a structural genomics pilot study. Mevalonate-5-diphosphate decarboxylase (MDD) is a single-domain alpha/beta protein that catalyzes the last of three sequential ATP-dependent reactions which convert mevalonate to isopentenyl diphosphate. Isopentenyl disphosphate isomerase (IDI) is an alpha/beta metalloenzyme that catalyzes interconversion of isopentenyl diphosphate and dimethylallyl diphosphate ...[more]