Ontology highlight
ABSTRACT:
SUBMITTER: Xiong W
PROVIDER: S-EPMC6080133 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Xiong Wei W Chen Yuhui Y Kang Xi X Chen Zhiying Z Zheng Peilin P Hsu Yi-Hsin YH Jang Joon Hee JH Qin Lidong L Liu Hao H Dotti Gianpietro G Liu Dongfang D
Molecular therapy : the journal of the American Society of Gene Therapy 20180302 4
Chimeric antigen receptor (CAR)-modified T cell therapy has the potential to improve the overall survival of patients with malignancies by enhancing the effectiveness of CAR T cells. Precisely predicting the effectiveness of various CAR T cells represents one of today's key unsolved problems in immunotherapy. Here, we predict the effectiveness of CAR-modified cells by evaluating the quality of the CAR-mediated immunological synapse (IS) by quantitation of F-actin, clustering of tumor antigen, po ...[more]