Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC6080135 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Wang Xiaowei X Searle Amy Kate AK Hohmann Jan David JD Liu Ao Leo AL Abraham Meike-Kristin MK Palasubramaniam Jathushan J Lim Bock B Yao Yu Y Wallert Maria M Yu Eefang E Chen Yung-Chih YC Peter Karlheinz K
Molecular therapy : the journal of the American Society of Gene Therapy 20180216 4
Abdominal aortic aneurysm (AAA) is an often deadly disease without medical, non-invasive treatment options. The upregulation of vascular cell adhesion molecule-1 (VCAM-1) on aortic endothelium provides an early target epitope for a novel biotechnological theranostic approach. MicroRNA-126 was used as a therapeutic agent, based on its capability to downregulate VCAM-1 expression in endothelial cells and thereby reduces leukocyte adhesion and exerts anti-inflammatory effects. Ultrasound microbubbl ...[more]