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Detection and localization of surgically resectable cancers with a multi-analyte blood test.

ABSTRACT: Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1005 patients with nonmetastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types. The sensitivities ranged from 69 to 98% for the detection of five cancer types (ovary, liver, stomach, pancreas, and esophagus) for which there are no screening tests available for average-risk individuals. The specificity of CancerSEEK was greater than 99%: only 7 of 812 healthy controls scored positive. In addition, CancerSEEK localized the cancer to a small number of anatomic sites in a median of 83% of the patients.

SUBMITTER: Cohen JD 

PROVIDER: S-EPMC6080308 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Detection and localization of surgically resectable cancers with a multi-analyte blood test.

Cohen Joshua D JD   Li Lu L   Wang Yuxuan Y   Thoburn Christopher C   Afsari Bahman B   Danilova Ludmila L   Douville Christopher C   Javed Ammar A AA   Wong Fay F   Mattox Austin A   Hruban Ralph H RH   Wolfgang Christopher L CL   Goggins Michael G MG   Dal Molin Marco M   Wang Tian-Li TL   Roden Richard R   Klein Alison P AP   Ptak Janine J   Dobbyn Lisa L   Schaefer Joy J   Silliman Natalie N   Popoli Maria M   Vogelstein Joshua T JT   Browne James D JD   Schoen Robert E RE   Brand Randall E RE   Tie Jeanne J   Gibbs Peter P   Wong Hui-Li HL   Mansfield Aaron S AS   Jen Jin J   Hanash Samir M SM   Falconi Massimo M   Allen Peter J PJ   Zhou Shibin S   Bettegowda Chetan C   Diaz Luis A LA   Tomasetti Cristian C   Kinzler Kenneth W KW   Vogelstein Bert B   Lennon Anne Marie AM   Papadopoulos Nickolas N  

Science (New York, N.Y.) 20180118 6378

Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1005 patients with nonmetastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types. The sensitivities range  ...[more]

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