Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez JN
PROVIDER: S-EPMC6080616 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Sanchez Jaquelyn N JN Wang Ton T Cohen Mark S MS
Drugs 20180401 5
The mitogen activated protein kinase/extracellular signal-related kinase (MAPK/ERK) signaling pathway serves an integral role in growth, proliferation, differentiation, migration, and survival of all mammalian cells. Aberrant signaling of this pathway is often observed in several types of hematologic and solid malignancies. The most frequent insult to this signaling cascade, leading to its constitutive activation, is to the serine/threonine kinase rapidly accelerating fibrosarcoma (RAF). Conside ...[more]