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The prognostic role of pretreatment thrombocytosis in gastric cancer: A systematic review and meta-analysis.
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ABSTRACT: Background
The association between platelet count and the prognosis of patients with gastric cancer has already been reported by numerous studies. As the reports are inconsistent, we conducted this meta-analysis to evaluate the prognostic significance of platelet count in patients with gastric cancer.Methods
A comprehensive search was performed in PubMed, Embase, and the Cochrane Library to identify relevant studies, which evaluated the prognostic impact of pretreatment platelet count in patients with gastric cancer. Data was pooled using a random effect model to calculate hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs).Results
Around 10 studies were included, comprising 8166 patients in total. The result showed that patients with thrombocytosis had significant worse overall survival (HR 1.57, 95% CI 1.36-1.81, P?ConclusionPretreatment thrombocytosis is a potential effective predictor of overall survival (OS) for patients with gastric cancer and is correlated with higher risks of recurrence, serosal invasion, and advanced stage.
SUBMITTER: Yang C
PROVIDER: S-EPMC6081180 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
The prognostic role of pretreatment thrombocytosis in gastric cancer: A systematic review and meta-analysis.
Medicine 20180801 31
<h4>Background</h4>The association between platelet count and the prognosis of patients with gastric cancer has already been reported by numerous studies. As the reports are inconsistent, we conducted this meta-analysis to evaluate the prognostic significance of platelet count in patients with gastric cancer.<h4>Methods</h4>A comprehensive search was performed in PubMed, Embase, and the Cochrane Library to identify relevant studies, which evaluated the prognostic impact of pretreatment platelet ...[more]