Dataset Information

Spontaneous regression of locally advanced nonsmall cell lung cancer: A case report.

ABSTRACT:

Rationale

Spontaneous regression of non-small cell lung cancer is exceptionally rare.

Patient concerns

Treatment-related toxicity.

Diagnoses

We report a case of a patient diagnosed with locally advanced non-small cell lung cancer.

Interventions

The patient declined potentially curative treatment, and did not receive any anti-cancer treatment.

Outcomes

He has survived more than two years since his initial diagnosis, maintaining his good performance status. Serial imaging with computed tomography scans showed tumour regression and near-complete resolution of his disease.

Lessons

Spontaneous regression of non-small cell lung cancer, by virtue of its scarcity, has not been well-studied and is poorly understood. Further studies are required, in order to clarify the mechanisms by which spontaneous regression occurs, and possibly identify new targets for cancer treatment.

SUBMITTER: Ooi KH

PROVIDER: S-EPMC6081199 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Publications

Spontaneous regression of locally advanced nonsmall cell lung cancer: A case report.

Ooi Kiat Huat KH Cheo Timothy T Soon Gwyneth Shook Ting GST Leong Cheng Nang CN

Medicine 20180801 31

<h4>Rationale</h4>Spontaneous regression of non-small cell lung cancer is exceptionally rare.<h4>Patient concerns</h4>Treatment-related toxicity.<h4>Diagnoses</h4>We report a case of a patient diagnosed with locally advanced non-small cell lung cancer.<h4>Interventions</h4>The patient declined potentially curative treatment, and did not receive any anti-cancer treatment.<h4>Outcomes</h4>He has survived more than two years since his initial diagnosis, maintaining his good performance status. Seri ...[more]

PMID: 30075496

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Project description:BackgroundConventional nutritional supplements are not or only partly successful in inducing protein accretion in advanced cancer, suggesting an attenuated anabolic response. To prevent muscle wasting and its deleterious consequences, generating an anabolic response is crucial. Dietary essential amino acids (EAA) have anabolic properties in other wasting diseases; however, data in advanced cancer are lacking.Patients and methodsIn 13 patients with advanced nonsmall-cell lung cancer (NSCLC) (stage III and IV) and 11 healthy age-matched subjects, we measured protein synthesis and breakdown of the whole body, and net protein anabolism (difference between protein synthesis and breakdown) after intake of 14 g of free EAA with high leucine levels (EAA/leucine) versus a balanced amino acid mixture containing both EAA and non-EAA as present in whey protein, according to a randomized, double-blind, crossover design.ResultsProtein synthesis and net protein anabolism were higher after intake of the EAA/leucine than the balanced amino acid mixture (P < 0.001), independent of presence of cancer. A highly significant linear relationship between net protein anabolism and the amount of EAA available in the systemic circulation (R(2): 0.85, P < 0.001) was found in both groups. The presence of muscle or recent weight loss, systemic inflammatory response, or length of survival did not influence this relationship. High leucine levels in the EAA/leucine mixture was of no anabolic benefit.ConclusionsThere is no anabolic resistance or attenuated anabolic potential to intake of 14 g of EAA/leucine or balanced amino acid mixture in advanced (mainly stage III) NSCLC. The high anabolic potential of dietary EAA in cancer patients is independent of their nutritional status, systemic inflammatory response or disease trajectory, suggesting a key role of EAA in new nutritional approaches to prevent muscle loss, thereby improving outcome of patients with advanced cancer.ClinicaltrailsgovNCT01172314.

Dataset Information

Spontaneous regression of locally advanced nonsmall cell lung cancer: A case report.

Rationale

Patient concerns

Diagnoses

Interventions

Outcomes

Lessons

Publications

Spontaneous regression of locally advanced nonsmall cell lung cancer: A case report.

Similar Datasets

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