Preclinical optimization of antibody-based radiopharmaceuticals for cancer imaging and radionuclide therapy-Model, vector, and radionuclide selection.
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ABSTRACT:
SUBMITTER: Carter LM
PROVIDER: S-EPMC6081268 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
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Preclinical optimization of antibody-based radiopharmaceuticals for cancer imaging and radionuclide therapy-Model, vector, and radionuclide selection.
Carter Lukas M LM Poty Sophie S Sharma Sai Kiran SK Lewis Jason S JS
Journal of labelled compounds & radiopharmaceuticals 20180330 9
Intact antibodies and their truncated counterparts (eg, Fab, scFv fragments) are generally exquisitely specific and selective vectors, enabling recognition of individual cancer-associated molecular phenotypes against a complex and dynamic biomolecular background. Complementary alignment of these advantages with unique properties of radionuclides is a defining paradigm in both radioimmunoimaging and radioimmunotherapy, which remain some of the most adept and promising tools for cancer diagnosis a ...[more]
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