Ontology highlight
ABSTRACT:
SUBMITTER: Voon HPJ
PROVIDER: S-EPMC6081460 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nature communications 20180807 1
An array of oncogenic histone point mutations have been identified across a number of different cancer studies. It has been suggested that some of these mutant histones can exert their effects by inhibiting epigenetic writers. Here, we report that the H3.3 G34R (glycine to arginine) substitution mutation, found in paediatric gliomas, causes widespread changes in H3K9me3 and H3K36me3 by interfering with the KDM4 family of K9/K36 demethylases. Expression of a targeted single-copy of H3.3 G34R at e ...[more]