Ontology highlight
ABSTRACT:
SUBMITTER: Kiripolsky J
PROVIDER: S-EPMC6082154 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Clinical immunology (Orlando, Fla.) 20170517
Animal models that recapitulate human disease are crucial for the study of Sjögren's Syndrome (SS). While several SS mouse models exist, there are few primary SS (pSS) models that mimic systemic disease manifestations seen in humans. Similar to pSS patients, NOD.B10Sn-H2<sup>b</sup>/J (NOD.B10) mice develop exocrine gland disease and anti-nuclear autoantibodies. However, the disease kinetics and spectrum of extra-glandular disease remain poorly characterized in this model. Our objective was to c ...[more]