Ontology highlight
ABSTRACT:
SUBMITTER: Silva-Sena GG
PROVIDER: S-EPMC6082243 | biostudies-literature | 2018 Apr./Jun
REPOSITORIES: biostudies-literature
Genetics and molecular biology 20180401 2
Human longevity is a polygenic and multifactorial trait. Pathways related to lifespan are complex and involve molecular, cellular, and environmental processes. In this analytical observational study, we evaluated the relationship between environment factors, oxidative stress status, DNA integrity level, and the association of FOXO3 (rs2802292), SOD2 (rs4880), APOE (rs429358 and rs7412), and SIRT1 (rs2273773) polymorphisms with longevity in oldest-old individuals from southeastern Brazil. We foun ...[more]