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Characterization of a NIR absorbing thienyl curcumin contrast agent for photoacoustic imaging.

ABSTRACT: The synthesis and characterization of a bis(2-dimethylaminothien-5-yl)curcumin boron difluoride chromophore is presented. Photophysical, electrochemical and computational investigations establish the properties of its absorption in the Vis-NIR spectral range relative to established curcumin dyes. Application of this thienyl curcumin dye as a photoacoustic contrast agent is investigated against the dicarbocyanine Cy5 dye in the 675-735 nm excitation range.

SUBMITTER: Bellinger S

PROVIDER: S-EPMC6082415 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Characterization of a NIR absorbing thienyl curcumin contrast agent for photoacoustic imaging.

Bellinger Stephanie S Hatamimoslehabadi Maryam M Borg Raymond E RE La Jeffrey J Catsoulis Peter P Mithila Farha F Yelleswarapu Chandra C Rochford Jonathan J

Chemical communications (Cambridge, England) 20180601 49

The synthesis and characterization of a bis(2-dimethylaminothien-5-yl)curcumin boron difluoride chromophore is presented. Photophysical, electrochemical and computational investigations establish the properties of its absorption in the Vis-NIR spectral range relative to established curcumin dyes. Application of this thienyl curcumin dye as a photoacoustic contrast agent is investigated against the dicarbocyanine Cy5 dye in the 675-735 nm excitation range. ...[more]

PMID: 29868656

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