Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC6082695 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20180801 8
Epigenetic information is encoded in the mammalian genome in the form of cytosines methylated at the 5 position. Cytosine methylation has multiple biological effects, but our understanding of these effects has lagged because extant methods for mapping methylation sites genome-wide have severe shortcomings. For instance, the gold standard bisulfite sequencing approach suffers from the use of harsh reaction conditions resulting in DNA cleavage and incomplete conversion of unmethylated cytosine to ...[more]