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Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates.

ABSTRACT: Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection.

SUBMITTER: Dudley DM 

PROVIDER: S-EPMC6082723 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates.

Dudley Dawn M DM   Van Rompay Koen K KK   Coffey Lark L LL   Ardeshir Amir A   Keesler Rebekah I RI   Bliss-Moreau Eliza E   Grigsby Peta L PL   Steinbach Rosemary J RJ   Hirsch Alec J AJ   MacAllister Rhonda P RP   Pecoraro Heidi L HL   Colgin Lois M LM   Hodge Travis T   Streblow Daniel N DN   Tardif Suzette S   Patterson Jean L JL   Tamhankar Manasi M   Seferovic Maxim M   Aagaard Kjersti M KM   Martín Claudia Sánchez-San CS   Chiu Charles Y CY   Panganiban Antonito T AT   Veazey Ronald S RS   Wang Xiaolei X   Maness Nicholas J NJ   Gilbert Margaret H MH   Bohm Rudolf P RP   Adams Waldorf Kristina M KM   Gale Michael M   Rajagopal Lakshmi L   Hotchkiss Charlotte E CE   Mohr Emma L EL   Capuano Saverio V SV   Simmons Heather A HA   Mejia Andres A   Friedrich Thomas C TC   Golos Thaddeus G TG   O'Connor David H DH  

Nature medicine 20180702 8

Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection. ...[more]

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