Ontology highlight
ABSTRACT:
SUBMITTER: Ariffin MZ
PROVIDER: S-EPMC6082830 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Ariffin Mohammed Zacky MZ Ibrahim Khairunisa Mohamad KM Lee Andy Thiam-Huat AT Lee Rui Zhi RZ Poon Shou Yu SY Thong Hwai Kit HK Liu Eugene Hern Choon EHC Low Chian-Ming CM Khanna Sanjay S
Scientific reports 20180808 1
The present study explored the role of the medial septal region (MS) in experimental neuropathic pain. For the first time, we found that the MS sustains nociceptive behaviors in rodent models of neuropathic pain, especially in the chronic constriction injury (CCI) model and the paclitaxel model of chemotherapy-induced neuropathic pain. For example, inactivation of the MS with intraseptal muscimol (2 μg/μl, 0.5 μl), a GABA mimetic, reversed peripheral hypersensitivity (PH) in the CCI model and in ...[more]