Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases.

ABSTRACT: BACKGROUND:Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease for which the genetic contribution is incompletely understood. METHODS:We conducted a joint analysis of 5,523,934 imputed SNPs in two newly-genotyped progressive supranuclear palsy cohorts, primarily derived from two clinical trials (Allon davunetide and NNIPPS riluzole trials in PSP) and a previously published genome-wide association study (GWAS), in total comprising 1646 cases and 10,662 controls of European ancestry. RESULTS:We identified 5 associated loci at a genome-wide significance threshold P?

SUBMITTER: Chen JA 

PROVIDER: S-EPMC6083608 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature