Cooperative Contraction Behaviors of a One-Dimensional Cell Chain.

ABSTRACT: Collective behaviors of multiple cells play important roles in various physiological and pathological processes, but the mechanisms of coordination among cells are highly unknown. Here, we build a one-dimensional cell-chain model to quantitatively study cell cooperativity. Combining experimental and theoretical approaches, we showed that the matrix stiffness, intercellular adhesion strength, and cell-chain length have a significant effect on the cooperative contraction of the cell chains. Cells have strong cooperativity, i.e., exhibiting a united contraction mode, in shorter cell chains or on softer matrix or with higher intercellular adhesion strength. In contrast, cells would exhibit a divided contraction when the cell chain was long or on stiffer matrix or with weaker adhesion strength.

SUBMITTER: Li X 

PROVIDER: S-EPMC6084254 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature