Skeletal muscle interleukin-6 regulates metabolic factors in iWAT during HFD and exercise training.
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ABSTRACT:
SUBMITTER: Knudsen JG
PROVIDER: S-EPMC6084358 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Skeletal muscle interleukin-6 regulates metabolic factors in iWAT during HFD and exercise training.
Knudsen Jakob G JG Bertholdt Laerke L Joensen Ella E Lassen Signe B SB Hidalgo Juan J Pilegaard Henriette H
Obesity (Silver Spring, Md.) 20150622 8
<h4>Objective</h4>To investigate the role of skeletal muscle (SkM) interleukin (IL)-6 in the regulation of adipose tissue metabolism.<h4>Methods</h4>Muscle-specific IL-6 knockout (IL-6 MKO) and IL-6(loxP/loxP) (Floxed) mice were subjected to standard rodent diet (Chow), high-fat diet (HFD), or HFD in combination with exercise training (HFD ExTr) for 16 weeks.<h4>Results</h4>Total fat mass increased (P < 0.05) in both genotypes with HFD. However, HFD IL-6 MKO mice had lower (P < 0.05) inguinal ad ...[more]
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