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Skeletal muscle interleukin-6 regulates metabolic factors in iWAT during HFD and exercise training.

ABSTRACT: To investigate the role of skeletal muscle (SkM) interleukin (IL)-6 in the regulation of adipose tissue metabolism.Muscle-specific IL-6 knockout (IL-6 MKO) and IL-6(loxP/loxP) (Floxed) mice were subjected to standard rodent diet (Chow), high-fat diet (HFD), or HFD in combination with exercise training (HFD ExTr) for 16 weeks.Total fat mass increased (P?

SUBMITTER: Knudsen JG 

PROVIDER: S-EPMC6084358 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Skeletal muscle interleukin-6 regulates metabolic factors in iWAT during HFD and exercise training.

Knudsen Jakob G JG   Bertholdt Laerke L   Joensen Ella E   Lassen Signe B SB   Hidalgo Juan J   Pilegaard Henriette H  

Obesity (Silver Spring, Md.) 20150622 8

<h4>Objective</h4>To investigate the role of skeletal muscle (SkM) interleukin (IL)-6 in the regulation of adipose tissue metabolism.<h4>Methods</h4>Muscle-specific IL-6 knockout (IL-6 MKO) and IL-6(loxP/loxP) (Floxed) mice were subjected to standard rodent diet (Chow), high-fat diet (HFD), or HFD in combination with exercise training (HFD ExTr) for 16 weeks.<h4>Results</h4>Total fat mass increased (P < 0.05) in both genotypes with HFD. However, HFD IL-6 MKO mice had lower (P < 0.05) inguinal ad  ...[more]

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