Ontology highlight
ABSTRACT:
SUBMITTER: De Iuliis V
PROVIDER: S-EPMC6084397 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
De Iuliis Vincenzo V Marino Antonio A Caruso Marika M Capodifoglio Sabrina S Flati Vincenzo V Marynuk Anna A Marricareda Valeria V Ursi Sebastiano S Lanuti Paola P Talora Claudio C Conti Pio P Martinotti Stefano S Toniato Elena E
Oncotarget 20180713 54
Autophagy is a not well-understood conserved mechanism activated during nutritional deprivation in order to maintain cellular homeostasis. In the present study, we investigated the correlations between autophagy, apoptosis and the MAPK pathways in melanoma cell lines. We demonstrated that during starvation the EGF receptor mediated signaling activates many proteins involved in the MAPK pathway. Our data also suggest a previously unidentified link between the EGFR and Beclin-1 in melanoma cell li ...[more]