Ontology highlight
ABSTRACT:
SUBMITTER: Vreven T
PROVIDER: S-EPMC6084434 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Vreven Thom T Schweppe Devin K DK Chavez Juan D JD Weisbrod Chad R CR Shibata Sayaka S Zheng Chunxiang C Bruce James E JE Weng Zhiping Z
Journal of molecular biology 20180414 12
Ab initio protein-protein docking algorithms often rely on experimental data to identify the most likely complex structure. We integrated protein-protein docking with the experimental data of chemical cross-linking followed by mass spectrometry. We tested our approach using 19 cases that resulted from an exhaustive search of the Protein Data Bank for protein complexes with cross-links identified in our experiments. We implemented cross-links as constraints based on Euclidean distance or void-vol ...[more]