Ontology highlight
ABSTRACT:
SUBMITTER: El-Gamal MI
PROVIDER: S-EPMC6084503 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
El-Gamal Mohammed I MI El-Gamal Mohammed I MI Oh Chang-Hyun CH
Journal of enzyme inhibition and medicinal chemistry 20181201 1
A series of eighteen pyrrolo[3,2-c]pyridine derivatives were tested for inhibitory effect against FMS kinase. Compounds 1e and 1r were the most potent among all the other tested analogues (IC<sub>50</sub> = 60 nM and 30 nM, respectively). They were 1.6 and 3.2 times, respectively, more potent than our lead compound, KIST101029 (IC<sub>50</sub> = 96 nM). Compound 1r was tested over a panel of 40 kinases including FMS, and exerted selectivity against FMS kinase. It was further tested against bone ...[more]