Ontology highlight
ABSTRACT:
SUBMITTER: Duncan OF
PROVIDER: S-EPMC6085068 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Duncan Olivia F OF Granat Lucy L Ranganathan Ramya R Singh Vandana K VK Mazaud David D Fanto Manolis M Chambers David D Ballard Clive G CG Bateman Joseph M JM
PLoS genetics 20180730 7
Mitochondrial dysfunction activates the mitochondrial retrograde signaling pathway, resulting in large scale changes in gene expression. Mitochondrial retrograde signaling in neurons is poorly understood and whether retrograde signaling contributes to cellular dysfunction or is protective is unknown. We show that inhibition of Ras-ERK-ETS signaling partially reverses the retrograde transcriptional response to alleviate neuronal mitochondrial dysfunction. We have developed a novel genetic screen ...[more]