Dataset Information

Macular ganglion cells alteration in a patient with left homonymous hemianopia subsequent to surgical excision of an arteriovenous malformation.

ABSTRACT:

Purpose

To report the case of a 57 years old woman who showed a macular ganglion cell complex (GCC), that is a combination of ganglion cell layer and inner plexiform layer, and peripapillary Retinal Nerve Fiber Layer (pRNFL) thickness reduction in association with left homonymous hemianopia subsequent to surgical excision of an arteriovenous malformation in the cerebral right occipital lobe 37 years before.

Observations

One patient with left homonymous hemianopia due to surgical excision of an arteriovenous malformation in the right cerebral occipital lobe came to our attention for transient blurred vision.Measurement of the GCC and pRNFL thickness was performed using spectral domain optical coherence tomography (SDOCT; Cirrus HD-OCT model 400). Visual field (VF) defects were assessed using Humphrey field analyzer using the central 30-2 Swedish Interactive Threshold Algorithm (SITA) program with appropriate trial lenses (Humphrey Field Analyzer II, Carl Zeiss Meditech, Inc, Dublin, California).The average pRNFL thickness was bilaterally reduced, showing a symmetry value of 39%. The patients showed a significant GCC thinning in the projecting sector of the retina mapping to the brain lesion. Corresponding VF defects were found.

Conclusions and importance

These findings show SDOCT potentials in the field of neuro-ophthalmology, supporting the usefulness of GCC thickness as a possible imaging marker before and after brain surgery, and, possibly, in the diagnosis of neurodegenerative conditions.

SUBMITTER: Martucci A

PROVIDER: S-EPMC6085272 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Publications

Macular ganglion cells alteration in a patient with left homonymous hemianopia subsequent to surgical excision of an arteriovenous malformation.

Martucci Alessio A Cesareo Massimo M Nucci Carlo C Mancino Raffaele R

American journal of ophthalmology case reports 20180801

<h4>Purpose</h4>To report the case of a 57 years old woman who showed a macular ganglion cell complex (GCC), that is a combination of ganglion cell layer and inner plexiform layer, and peripapillary Retinal Nerve Fiber Layer (pRNFL) thickness reduction in association with left homonymous hemianopia subsequent to surgical excision of an arteriovenous malformation in the cerebral right occipital lobe 37 years before.<h4>Observations</h4>One patient with left homonymous hemianopia due to surgical e ...[more]

PMID: 30105312

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Project description:BACKGROUND:Pulmonary arteriovenous malformations are abnormal direct connections between the pulmonary artery and pulmonary vein which result in a right-to-left shunt. They are associated with substantial morbidity and mortality mainly from the effects of paradoxical emboli. Potential complications include stroke, cerebral abscess, pulmonary haemorrhage and hypoxaemia. Embolisation is an endovascular intervention based on the occlusion of the feeding arteries the pulmonary arteriovenous malformations thus eliminating the abnormal right-to-left-shunting. This is an update of a previously published review. OBJECTIVES:To determine the efficacy and safety of embolisation in patients with pulmonary arteriovenous malformations including a comparison with surgical resection and different embolisation devices. SEARCH METHODS:We searched the Cystic Fibrosis and Genetic Disorders Group's Trials Register; date of last search: 10 April 2017.We also searched the following databases: the Australian New Zealand Clinical Trials Registry; ClinicalTrials.gov; International Standard Randomised Controlled Trial Number Register; International Clinical Trials Registry Platform Search Portal (last searched 27 August 2017). to be updatedWe checked cross-references and searched references from review articles. SELECTION CRITERIA:Trials in which individuals with pulmonary arteriovenous malformations were randomly allocated to embolisation compared to no treatment, surgical resection or embolisation using a different embolisation device. DATA COLLECTION AND ANALYSIS:Studies identified for potential inclusion were independently assessed for eligibility by two authors, with excluded studies further checked by a third author. No trials were identified for inclusion in the review and hence no analysis was performed. MAIN RESULTS:There were no randomised controlled trials included in the review; one ongoing trial has been identified which may be eligible for inclusion in the future. AUTHORS' CONCLUSIONS:There is no evidence from randomised controlled trials for embolisation of pulmonary arteriovenous malformations. However, randomised controlled trials are not always feasible on ethical grounds. Accumulated data from observational studies suggest that embolisation is a safe procedure which reduces morbidity and mortality. A standardised approach to reporting with long-term follow-up through registry studies can help to strengthen the evidence for embolisation in the absence of randomised controlled trials.

Dataset Information

Macular ganglion cells alteration in a patient with left homonymous hemianopia subsequent to surgical excision of an arteriovenous malformation.

Purpose

Observations

Conclusions and importance

Publications

Macular ganglion cells alteration in a patient with left homonymous hemianopia subsequent to surgical excision of an arteriovenous malformation.

Similar Datasets

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