Ontology highlight
ABSTRACT:
SUBMITTER: Shin JH
PROVIDER: S-EPMC6085294 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Shin Ji Hye JH Park Chang Wook CW Yoon Gyesoon G Hong Sun Mi SM Choi Kwan Yong KY
Oncogenesis 20180810 8
Nicotinamide N-methyl transferase (NNMT) transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide (NAM), producing 1-methylnicotinamide (1MNA). NNMT has been implicated in several cancer types and recently in metabolism, but its role in autophagy regulation has not yet been investigated. In this study, we determined that NNMT negatively regulated autophagy at the stage of ULK1 activation through protein phosphatase 2A (PP2A) activity. Specifically, NNMT knockdown increased PP2 ...[more]