A Systems-Level Analysis Reveals Circadian Regulation of Splicing in Colorectal Cancer.

ABSTRACT: Accumulating evidence points to a significant role of the circadian clock in the regulation of splicing in various organisms, including mammals. Both dysregulated circadian rhythms and aberrant pre-mRNA splicing are frequently implicated in human disease, in particular in cancer. To investigate the role of the circadian clock in the regulation of splicing in a cancer progression context at the systems-level, we conducted a genome-wide analysis and compared the rhythmic transcriptional profiles of colon carcinoma cell lines SW480 and SW620, derived from primary and metastatic sites of the same patient, respectively. We identified spliceosome components and splicing factors with cell-specific circadian expression patterns including SRSF1, HNRNPLL, ESRP1, and RBM 8A, as well as altered altern

SUBMITTER: El-Athman R 

PROVIDER: S-EPMC6085510 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature