ChromTime: modeling spatio-temporal dynamics of chromatin marks.
Ontology highlight
ABSTRACT:
SUBMITTER: Fiziev P
PROVIDER: S-EPMC6085762 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
ChromTime: modeling spatio-temporal dynamics of chromatin marks.
Genome biology 20180810 1
To model spatial changes of chromatin mark peaks over time we develop and apply ChromTime, a computational method that predicts peaks to be either expanding, contracting, or holding steady between time points. Predicted expanding and contracting peaks can mark regulatory regions associated with transcription factor binding and gene expression changes. Spatial dynamics of peaks provide information about gene expression changes beyond localized signal density changes. ChromTime detects asymmetric ...[more]
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