Ontology highlight
ABSTRACT:
SUBMITTER: Kainulainen MH
PROVIDER: S-EPMC6086598 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Kainulainen Markus H MH Spengler Jessica R JR Welch Stephen R SR Coleman-McCray JoAnn D JD Harmon Jessica R JR Klena John D JD Nichol Stuart T ST Albariño César G CG Spiropoulou Christina F CF
The Journal of infectious diseases 20180501 12
Lassa fever is a viral zoonosis that can be transmitted from person to person, especially in the hospital setting. The disease is endemic to several countries in West Africa and can be a major contributor to morbidity and mortality in affected areas. There are no approved vaccines to prevent Lassa virus infection. In this work, we present a vaccine candidate that combines the scalability and efficacy benefits of a live vaccine with the safety benefits of single-cycle replication. The system cons ...[more]